The dendrites receive a signal, the axon hillock funnels the signal to the initial segment and the initial segment triggers the activity (action potential) that is sent along the axon towards the synapse. Synapses allow neurons to activate other neurons. Schwann cells make activity move faster down axon. The neuron contains dendrites that receives information, a cell body called the soma, and an axon that sends information. For other uses, see Dendrite (disambiguation). All rights reserved.This article is about neuronal dendrites in biology. In summary, neuronal excitability in response to distributed synaptic inputs is largely unaffected by dendrite length or complexity.Ĭable theory compartmental model electrotonic analysis excitability morphological model neuronal scaling passive normalization.Ĭopyright © 2021 Elsevier Inc. In contrast to spike rate, spike times do depend on dendrite morphology. Spiking models indicate that morphology-invariant numbers of spikes approximate the percentage of active synapses. This remains valid for a wide range of morphologies irrespective of their arborization complexity. For a given synaptic density, neuronal responses depend only on the average dendritic diameter and intrinsic conductivity. Here we use analytical cable theory to predict voltage responses to distributed synaptic inputs in unbranched cables, showing that these are entirely independent of dendritic length. However, the impact of a neuron's size and shape on its voltage responses to dendritic synaptic activation is much less understood. Smaller neurons are thus more excitable, as seen in their responses to somatic current injections. Reducing neuronal size results in less membrane and therefore lower input conductance. 6 Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University, 60590 Frankfurt am Main, Germany.5 Ernst Strüngmann Institute (ESI) for Neuroscience in cooperation with the Max Planck Society, 60528 Frankfurt am Main, Germany Frankfurt Institute for Advanced Studies, 60438 Frankfurt am Main, Germany.4 Ernst Strüngmann Institute (ESI) for Neuroscience in cooperation with the Max Planck Society, 60528 Frankfurt am Main, Germany Frankfurt Institute for Advanced Studies, 60438 Frankfurt am Main, Germany Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University, 60590 Frankfurt am Main, Germany Max Planck Institute for Brain Research, 60438 Frankfurt am Main, Germany.3 Frankfurt Institute for Advanced Studies, 60438 Frankfurt am Main, Germany ICAR3R - Interdisciplinary Centre for 3Rs in Animal Research, Justus Liebig University Giessen, 35390 Giessen, Germany Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University, 60590 Frankfurt am Main, Germany.Electronic address: 2 Ernst Strüngmann Institute (ESI) for Neuroscience in cooperation with the Max Planck Society, 60528 Frankfurt am Main, Germany Frankfurt Institute for Advanced Studies, 60438 Frankfurt am Main, Germany ICAR3R - Interdisciplinary Centre for 3Rs in Animal Research, Justus Liebig University Giessen, 35390 Giessen, Germany. 1 Ernst Strüngmann Institute (ESI) for Neuroscience in cooperation with the Max Planck Society, 60528 Frankfurt am Main, Germany Frankfurt Institute for Advanced Studies, 60438 Frankfurt am Main, Germany.
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